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DS Technology Platforms
Flow Chemistry Synthetic Biology & Biocatalysis Highly Potent Compound Peptide TPD/PROTAC Oligonucleotide Synthesis Crystallization & Particle Engineering Preparation & Separation
Flow Chemistry Platform
Apeloa has established an industry-leading flow chemistry platform with over a decade of flow chemistry experience, a multi-site network of manufacturing, development, and analytical facilities, combined with world-class scientists. Our state-of-the-art facilities offer quick and economical viable solutions to tackle process challenges under conventional batch mode, with services from feasibility, process development and optimization (PD&O), scale-up to commercial production.
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Team
Our flow chemistry services are supported by highly educated and experienced teams across our global network facilities. Our Boston (USA) site offers leading expertise in early-stage flow chemistry, while our Shanghai and Hengdian (China) sites can efficiently develop gram to kilogram scale samples, supported by advanced analytical technology and skilled scientists.
Service
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Apeloa offers comprehensive flow chemistry expertise covering the entire lifecycle, from early development to manufacturing of intermediates and active pharmaceutical ingredients (APIs).
Feasibility study (FTE/FFS for early stage development)
Process development & optimization (PD&O)
Scale-up and Proof of concept study
Commercial equipment design
Variable scale sample preparation
Non-GMP and cGMP commercial manufacturing
The advantages of fluid chemistry: green, safe, economical, fast, and flexible
Flow Chemistry Reactions
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Flow chemistry can be an ideal approach for synthesis routes involving high-risk conditions, such as highly exothermic, explosive, light-activated, or highly complex multi-step synthesis routes. Apeloa has demonstrated scientific excellence with a wide range of flow chemistry reactions.
Range of Flow Chemistry Reactors
Apeloa has built a full complement of flow chemistry reactors for different scale and stage of development, including lab-scale reactors (g to 1kg scale) and Non-GMP & cGMP commercial production scale reactors (up to tons/year).
Laboratory scale fluid reactor :
Microreactors (stainless steel, silicon carbide, Hastelloy&glass)
Tubular reactors (stainless steel and Hastelloy)
Tangential reactor (stainless steel and Hastelloy)
Photoreactor (light) with adjustable UVLED radiation and glass tube
Circulating reactor
Non GMP/GMP commercial scale fluid reactors :
Microreactor
Tubular reactor (Monel alloy)
Tubular reactor (stainless steel 316L)
  • MICRO REACTOR
    MICRO REACTOR
  • TUBULAR REACTOR
    TUBULAR REACTOR
  • CSTR
    CSTR
  • TANGENTIAL REACTOR(HC)
    TANGENTIAL REACTOR(HC)
  • PHOTO REACTOR
    PHOTO REACTOR
  • MICRO REACTOR-Glass
    MICRO REACTOR-Glass
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MICRO REACTOR
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TUBULAR REACTOR
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CSTR
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TANGENTIAL REACTOR(HC)
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PHOTO REACTOR
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MICRO REACTOR-Glass
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